Brandon J. DeKosky

School of Engineering - Pharmaceutical Chemistry, Chemical & Petroleum Engineering
Assistant Professor
Ph.D.
Primary office:
785-864-2468
Learned Hall
University of Kansas
2095 Constant Ave
Lawrence 66047


Summary

Education

Ph.D., Chemical Engineering, University of Texas at Austin

B.S., Chemical Engineering, University of Kansas

Selected Publications

Duan, H. Chen, X. Boyington, J. C., Cheng, C. Zhang, Y. Jafari, A. J., Stephens, T. Tsybovsky, Y. Kalyuzhniy, O. Menis, S. Nason, M. C., Normandin, E. Mukhamedova, M. DeKosky, B. J., Wells, L. Schief, W. R., Tian, M. Alt, F. Kwong, P. D., & Mascola, J. R. (2018). Glycan-masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies. Immunity. DOI:10.1016/j.immuni.2018.07.005

Wang, B. DeKosky, B. J., Timm, M. R., Lee, J. Normandin, E. Misasi, J. Kong, R. McDaniel, J. R., Delidakis, G. Leigh, K. E., Niezold, T. Choi, C. W., Viox, E. G., Fahad, A. Cagigi, A. Ploquin, A. Leung, K. Yang, E. S., Kong, W. P., Voss, W. N., Schmidt, A. G., Moody, M. A., Ambrozak, D. R., Henry, A. R., Laboune, F. Ledgerwood, J. E., Graham, B. S., Connors, M. Douek, D. C., Sullivan, N. J., Ellington, A. D., Mascola, J. R., & Georgiou, G. (2018). Functional interrogation and mining of natively paired human VH:VL antibody repertoires. Nature biotechnology. DOI:10.1038/nbt.4052

DeKosky, B. J. (2017). Decoding the Antibody Repertoire: High Throughput Sequencing of Multiple Transcripts from Single B Cells, Springer International Publishing.

Kwong, P. D., Chuang, G. Y., DeKosky, B. J., Gindin, T. Georgiev, I. S., Lemmin, T. Schramm, C. A., Sheng, Z. Soto, C. Yang, A. S., Mascola, J. R., & Shapiro, L. (2017). Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1. Immunological reviews, 275(1), 108-128. DOI:10.1111/imr.12480

Lau, D. Lan, L. Y., Andrews, S. F., Henry, C. Rojas, K. T., Neu, K. E., Huang, M. Huang, Y. DeKosky, B. Palm, A. E., Ippolito, G. C., Georgiou, G. & Wilson, P. C. (2017). Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation. Science immunology, 2(7). DOI:10.1126/sciimmunol.aai8153

Lee, J. Boutz, D. R., Chromikova, V. Joyce, M. G., Vollmers, C. Leung, K. Horton, A. P., DeKosky, B. J., Lee, C. H., Lavinder, J. J., Murrin, E. M., Chrysostomou, C. Hoi, K. H., Tsybovsky, Y. Thomas, P. V., Druz, A. Zhang, B. Zhang, Y. Wang, L. Kong, W. P., Park, D. Popova, L. I., Dekker, C. L., Davis, M. M., Carter, C. E., Ross, T. M., Ellington, A. D., Wilson, P. C., Marcotte, E. M., Mascola, J. R., Ippolito, G. C., Krammer, F. Quake, S. R., Kwong, P. D., & Georgiou, G. (2016). Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination. Nature medicine, 22(12), 1456-1464. DOI:10.1038/nm.4224

Tian, M. Cheng, C. Chen, X. Duan, H. Cheng, H. L., Dao, M. Sheng, Z. Kimble, M. Wang, L. Lin, S. Schmidt, S. D., Du, Z. Joyce, M. G., Chen, Y. DeKosky, B. J., Chen, Y. Normandin, E. Cantor, E. Chen, R. E., Doria-Rose, N. A., Zhang, Y. Shi, W. Kong, W. P., Choe, M. Henry, A. R., Laboune, F. Georgiev, I. S., Huang, P. Y., Jain, S. McGuire, A. T., Georgeson, E. Menis, S. Douek, D. C., Schief, W. R., Stamatatos, L. Kwong, P. D., Shapiro, L. Haynes, B. F., Mascola, J. R., & Alt, F. W. (2016). Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires. Cell, 166(6), 1471-1484.e18. DOI:10.1016/j.cell.2016.07.029

DeKosky, B. J., Lungu, O. I., Park, D. Johnson, E. L., Charab, W. Chrysostomou, C. Kuroda, D. Ellington, A. D., Ippolito, G. C., Gray, J. J., & Georgiou, G. (2016). Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires. Proceedings of the National Academy of Sciences of the United States of America, 113(19), E2636-45. DOI:10.1073/pnas.1525510113

Murzabaev, M. Kojima, T. Mizoguchi, T. Kobayashi, I. DeKosky, B. J., Georgiou, G. & Nakano, H. (2016). Handmade microfluidic device for biochemical applications in emulsion. Journal of bioscience and bioengineering, 121(4), 471-6. DOI:10.1016/j.jbiosc.2015.08.001

McDaniel, J. R., DeKosky, B. J., Tanno, H. Ellington, A. D., & Georgiou, G. (2016). Ultra-high-throughput sequencing of the immune receptor repertoire from millions of lymphocytes. Nature protocols, 11(3), 429-42. DOI:10.1038/nprot.2016.024

Gorman, J. Soto, C. Yang, M. M., Davenport, T. M., Guttman, M. Bailer, R. T., Chambers, M. Chuang, G. Y., DeKosky, B. J., Doria-Rose, N. A., Druz, A. Ernandes, M. J., Georgiev, I. S., Jarosinski, M. C., Joyce, M. G., Lemmin, T. M., Leung, S. Louder, M. K., McDaniel, J. R., Narpala, S. Pancera, M. Stuckey, J. Wu, X. Yang, Y. Zhang, B. Zhou, T. Mullikin, J. C., Baxa, U. Georgiou, G. McDermott, A. B., Bonsignori, M. Haynes, B. F., Moore, P. L., Morris, L. Lee, K. K., Shapiro, L. Mascola, J. R., & Kwong, P. D. (2016). Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design. Nature structural & molecular biology, 23(1), 81-90. DOI:10.1038/nsmb.3144

Wang, B. Kluwe, C. A., Lungu, O. I., DeKosky, B. J., Kerr, S. A., Johnson, E. L., Jung, J. Rezigh, A. B., Carroll, S. M., Reyes, A. N., Bentz, J. R., Villanueva, I. Altman, A. L., Davey, R. A., Ellington, A. D., & Georgiou, G. (2015). Facile Discovery of a Diverse Panel of Anti-Ebola Virus Antibodies by Immune Repertoire Mining. Scientific reports, 5, 13926. DOI:10.1038/srep13926

DeKosky, B. J., Kojima, T. Rodin, A. Charab, W. Ippolito, G. C., Ellington, A. D., & Georgiou, G. (2015). In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire. Nature medicine, 21(1), 86-91. DOI:10.1038/nm.3743

Doria-Rose, N. A., Schramm, C. A., Gorman, J. Moore, P. L., Bhiman, J. N., DeKosky, B. J., Ernandes, M. J., Georgiev, I. S., Kim, H. J., Pancera, M. Staupe, R. P., Altae-Tran, H. R., Bailer, R. T., Crooks, E. T., Cupo, A. Druz, A. Garrett, N. J., Hoi, K. H., Kong, R. Louder, M. K., Longo, N. S., McKee, K. Nonyane, M. O'Dell, S. Roark, R. S., Rudicell, R. S., Schmidt, S. D., Sheward, D. J., Soto, C. Wibmer, C. K., Yang, Y. Zhang, Z. Mullikin, J. C., Binley, J. M., Sanders, R. W., Wilson, I. A., Moore, J. P., Ward, A. B., Georgiou, G. Williamson, C. Abdool Karim, S. S., Morris, L. Kwong, P. D., Shapiro, L. & Mascola, J. R. (2014). Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature, 509(7498), 55-62. DOI:10.1038/nature13036

Lavinder, J. J., Wine, Y. Giesecke, C. Ippolito, G. C., Horton, A. P., Lungu, O. I., Hoi, K. H., DeKosky, B. J., Murrin, E. M., Wirth, M. M., Ellington, A. D., Dörner, T. Marcotte, E. M., Boutz, D. R., & Georgiou, G. (2014). Identification and characterization of the constituent human serum antibodies elicited by vaccination. Proceedings of the National Academy of Sciences of the United States of America, 111(6), 2259-64. DOI:10.1073/pnas.1317793111

DeKosky, B. J., Ippolito, G. C., Deschner, R. P., Lavinder, J. J., Wine, Y. Rawlings, B. M., Varadarajan, N. Giesecke, C. Dörner, T. Andrews, S. F., Wilson, P. C., Hunicke-Smith, S. P., Willson, C. G., Ellington, A. D., & Georgiou, G. (2013). High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nature biotechnology, 31(2), 166-9. DOI:10.1038/nbt.2492

DeKosky, B. J., Dormer, N. H., Ingavle, G. C., Roatch, C. H., Lomakin, J. Detamore, M. S., & Gehrke, S. H. (2010). Hierarchically designed agarose and poly(ethylene glycol) interpenetrating network hydrogels for cartilage tissue engineering. Tissue engineering. Part C, Methods, 16(6), 1533-42. DOI:10.1089/ten.tec.2009.0761

Selected Awards & Honors

Cellular and Molecular Bioengineering Rising Star
Biomedical Engineering Society
2017


Upcoming Events and Deadlines

Nick Reding's Final Thesis Defense | Monday, November 25th | 9:00 - 10:00AM | 1 Eaton (Dean's Conference Room)

Dylan Jantz's Comprehensive Exam Defense | Monday, November 25th | 10:45 - 11:45AM | 298 Slawson Hall

Ahmad Ghoulum's Final Thesis Defense | Friday, December 6th | 1:00 - 3:00PM | 298 Slawson Hall


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