C Berkland

School of Engineering - Chemical & Petroleum Engineering, Pharmaceutical Chemistry
Solon E. Summerfield Distinguished Professor
Primary office:
785-864-1455
Multidisciplinary Research Building
Room 320D
University of Kansas
2030 Becker Drive
Lawrence, KS 66047
Second office:
785-864-4949
Learned Hall
Room 4160C



Summary

Education

Ph.D., Chemical and Biomolecular Engineering, University of Illinois

M.S., Chemical Engineering, University of Illinois

B.S., Chemical Engineering, Iowa State University

Selected Publications

Veisi, M. Johnson, S. Peltier, K. Berkland, C. Liang, J. & Barati, R. (2018). Application of Polyelectrolyte Complex Nanoparticles to Increase the Lifetime of Poly Vinyl Sulfonate Scale Inhibitor. In SPE International Conference and Exhibition on Formation Damage Control. Society of Petroleum Engineers. DOI:10.2118/189564-ms http://dx.doi.org/10.2118/189564-ms

Xie, S. X., Baoum, A. A., Alhakamy, N. A., & Berkland, C. J. (2018). Calcium enhances gene expression when using low molecular weight poly-l-lysine delivery vehicles. J. Pharm Sci, 547(1-2), 274-281.

Veisi, M. Johnson, S. Shafer-Peltier, K. Liang, J. Berkland, C. Chen, M. & Barati, R. (2018). Controlled release of poly(vinyl sulfonate) scale inhibitor to extend reservoir treatment lifetime. Journal of Applied Polymer Science, 136(12), 47225. DOI:10.1002/app.47225 http://dx.doi.org/10.1002/app.47225

Van Kampen, E. Vandervelden, C. Fakhari, A. Qian, J. Berkland, C. & Gehrke, S. H. (2018). Design of Hollow Hyaluronic Acid Cylinders for Sustained Intravitreal Protein Delivery. J. Pharm Sci, 107(9), 2354-2365.

Townsend, J. M., Zabel, T. A., Feng, Y. Wang, J. Andrews, B. T., Nudo, R. J., Berkland, C. J., & Detamore, M. S. (2018). Effects of tissue processing on bioactivity of cartilage matrix-based hydrogels encapsulating osteoconductive particles. BIOMEDICAL MATERIALS, 13(3). DOI:10.1088/1748-605X/aaad77

Dormer, N. H., Nelson-Brantley, J. Staecker, H. & Berkland, C. (2018). Evaluation of a transtympanic delivery system in Mus musculus for extended release steroids. European Journal of Pharmaceutical Sciences, S0928-0987(18), 30027-7.

Tima, S. Okonogi, S. Ampasavate, C. Berkland, C. & Anuchapreeda, S. (2018). FLT3-specific curcumin micelles enhance activity of curcumin on FLT3-ITD overexpressing MV4-11 leukemic cells. Drug Development and Industrial Pharmacy, 1-26. DOI:10.1080/03639045.2018.1562462 http://dx.doi.org/10.1080/03639045.2018.1562462

Song, J. Y., Larson, N. R., Thati, S. Torres-Vazquez, I. Martinez-Rivera, N. Subelzu-Aispuru, N. J., Leon, M. A., Rosa-Molinar, E. Schoeneich, C. Forrest, M. L., Middaugh, C. R., & Berkland, C. J. (2018). Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation. Journal of Controlled Release, 293, 36-47.

Ruiz, S. I., Bowen, L. E., Bailey, M. M., & Berkland, C. (2018). Pulmonary Delivery of Ceftazidime for the Treatment of Melioidosis in a Murine Model. MOLECULAR PHARMACEUTICS, 15(3), 1371-1376. DOI:10.1021/acs.molpharmaceut.7b00938

Hartwell, B. L., Pickens, C. J., Leon, M. Northrup, L. Christopher, M. Griffin, J. D., Martinez-Becerra, F. & Berkland, C. (2018). Soluble antigen arrays disarm antigen-specific B cells to promote lasting immune tolerance in experimental autoimmune encephalomyelitis. Journal of Autoimmunity, 93, 76-88.

Townsend, J. M., Andrews, B. T., Feng, Y. Wang, J. Nudo, R. J., Gehrke, S. H., Berkland, C. J., & Detamore, M. S. (2018). Superior calvarial bone regeneration using pentenoate-functionalized hyaluronic acid hydrogels with devitalized tendon particles. ACTA BIOMATERIALIA, 71, 148-155. DOI:10.1016/j.actbio.2018.02.013

Pickens, C. J., Johnson, S. N., Pressnall, M. M., Leon, M. A., & Berkland, C. J. (2018). Practical Considerations, Challenges, and Limitations of Bioconjugation via Azide-Alkyne Cycloaddition. BIOCONJUGATE CHEMISTRY, 29(3), 686-701. DOI:10.1021/acs.bioconjchem.7b00633

Pacelli, S. Basu, S. Berkland, C. Wang, J. & Paul, A. (2018). Design of a Cytocompatible Hydrogel Coating to Modulate Properties of Ceramic-Based Scaffolds for Bone Repair. Cellular and Molecular Bioengineering, 11(3), 211-217. DOI:10.1007/s12195-018-0521-3 http://dx.doi.org/10.1007/s12195-018-0521-3

Abdulhafiz Alhakamy, N. Berkland, C. J., & Dhar, P. (2018). Different Membrane Insertion Potential of Gene Nanoparticles Studied by using Phospholipid Monolayer and Bilayer Models. Biophysical Journal, 114(3), 443a. DOI:10.1016/j.bpj.2017.11.2448 http://dx.doi.org/10.1016/j.bpj.2017.11.2448

Ishiguro, S. Alhakamy, N. Uppalapati, D. Delzeit, J. Berkland, C. & Tamura, M. (2017). Combined local pulmonary and systemic delivery of AT2R gene by modified TAT peptide nanoparticles attenuates both murine and human lung carcinoma xenografts in mice. Journal of Pharmaceutical Sciences, 106(1), 385-394.

Teresk, M. G., Berkland, C. J., & Dormer, N. H. (2017). Deficiencies in Traditional Oral Dosage Forms and the Emergence of Controlled-Release Powder Manufacturing. KONA: Powder and Particle, 34, 91-105. DOI:10.14356/kona/2017013

Gupta, V. Khan, Y. Berkland, C. J., Laurencin, C. T., & Detamore, M. S. (2017). Microsphere-Based Scaffolds in Regenerative Engineering. Annual Reviews of Biomedical Engineering, 19, 135-161.

Hartwell, B. L., Pickens, C. J., Leon, M. & Berkland, C. (2017). Multivalent Soluble Antigen Arrays Exhibit High Avidity Binding and Modulation of B Cell Receptor-Mediated Signaling to Drive Efficacy against Experimental Autoimmune Encephalomyelitis. Biomacromolecules, 18(6), 1893-1907.

Shoults, C. C., Kearns, G. L., Meyer, A. R., Moran, J. D'Ann, P. Abdel-Rahman, S. M., Berkland, C. J., & Dormer, N. H. (2017). Pharmacokinetics of a Taste-Masked Prednisone Oral Microsphere Powder. Journal of Bioequivalence and Bioavailability, 9, 547-554.

Kuehl, C. Thati, S. Sullivan, B. Sestak, J. Thompson, M. Siahaan, T. & Berkland, C. (2017). Pulmonary Administration of Soluble Antigen Arrays Is Superior to Antigen in Treatment of Experimental Autoimmune Encephalomyelitis. Journal of Pharmaceutical Sciences, 106(11):3293-3302.

Northrup, L. Sullivan, B. P., Hartwell, B. L., Garza, A. & Berkland, C. (2017). Screening Immunomodulators To Skew the Antigen-Specific Autoimmune Response. Molecular Pharmaceutics, 14(1), 66-80.

Tima, S. Anuchapreeda, S. Ampasavate, C. Berkland, C. & Okonogi, S. (2017). Stable curcumin-loaded polymeric micellar formulation for enhancing cellular uptake and cytotoxicity to FLT3 overexpressing EoL-1 leukemic cells. European Journal of Pharmaceutics and Biopharmaceutics, 1114, 57-68.

Pacelli, S. Basu, S. Whitlow, J. Chakravarti, A. Acosta, F. Varshney, A. Modaresi, S. Berkland, C. & Paul, A. (2017). Strategies to develop endogenous stem cell-recruiting bioactive materials for tissue repair and regeneration. Advanced Drug Delivery Reviews, 120:50-70.

Townsend, J. M., Dennis, S. C., Whitlow, J. Feng, Y. Wang, J. Andrews, B. Nudo, R. J., Detamore, M. S., & Berkland, C. J. (2017). Colloidal Gels with Extracellular Matrix Particles and Growth Factors for Bone Regeneration in Critical Size Rat Calvarial Defects. The AAPS journal, 19(3), 703-711. DOI:10.1208/s12248-017-0045-0

Dennis, S. C., Whitlow, J. Detamore, M. S., Kieweg, S. L., & Berkland, C. J. (2017). Hyaluronic-Acid-Hydroxyapatite Colloidal Gels Combined with Micronized Native ECM as Potential Bone Defect Fillers. Langmuir: the ACS journal of surfaces and colloids, 33(1), 206-218. DOI:10.1021/acs.langmuir.6b03529

Hartwell, B. L., Martinez-Becerra, F. Chen, J. Shinogle, H. E., Sarnowski, M. Moore, D. S., & Berkland, C. (2016). Antigen-Specific Binding of Multivalent Soluble Antigen Arrays Induces Receptor Clustering and Impedes B Cell Receptor Mediated Signaling. Biomacromolecules, 17(3), 710-22.

Alhakamy, N. A., Dhar, P. & Berkland, C. J. (2016). Charge Type, Charge Spacing, and Hydrophobicity of Arginine-Rich Cell-Penetrating Peptides Dictate Gene Transfection. Molecular Pharmaceutics, 13(3), 1047-57.

Mohammadi, Z. Sun, S. Berkland, C. & Liang, J. T. (2016). Chelator-mimetic multi-functionalized hydrogel: Highly efficient and reusable sorbent for Cd, Pb, and As removal from waste water. Chemical Engineering Journal, 307, 496-502.

Beck, E. C., Barragan, M. Libeer, T. B., Kieweg, S. L., Converse, G. L., Hopkins, R. A., Berkland, C. J., & Detamore, M. S. (2016). Chondroinduction from Naturally Derived Cartilage Matrix: A Comparison Between Devitalized and Decellularized Cartilage Encapsulated in Hydrogel Pastes. Tissue Engineering Part A, 22(8-Jul), 665-679.

Ruiz, S. Bowen, L. Berkland, C. & Bailey, M. M. (2016). Formulation and Characterization of Nanocluster Ceftazidime for the Treatment of Acute Pulmonary Melioidosis. Journal of Pharmaceutical Sciences, 105(11), 3399-3408.

Kuehl, C. Zhang, T. Kaminskas, L. M., Porter, C. J., Davies, N. M., Forrest, L. & Berkland, C. (2016). Hyaluronic Acid Molecular Weight Determines Lung Clearance and Biodistribution after Instillation. Molecular Pharmaceutics, 13(6), 1904-14.

Sridharan, B. Mohan, N. Berkland, C. J., & Detamore, M. S. (2016). Material characterization of microsphere-based scaffolds with encapsulated raw materials. Material Science and Engineering C: Materials for Biological Applications, 63, 422-8.

Gupta, V. Tenny, K. M., Barragan, M. Berkland, C. J., & Detamore, M. S. (2016). Microsphere-based scaffolds encapsulating chondroitin sulfate or decellularized cartilage. Journal of Biomaterial Applications, 31(3), 328-343.

Gupta, V. Lyne, D. V., Barragan, M. Berkland, C. J., & Detamore, M. S. (2016). Microsphere-based scaffolds encapsulating tricalcium phosphate and hydroxyapatite for bone regeneration. Journal of Materials Science: Materials in Medicine, 27(7), 121.

Berkland, C. & Middaugh, C. R. (2016). Overcoming formulation challenges for the next generation of vaccines. Expert Opinion on Drug Delivery, 13(11), 1501-1502.

Antunez, L. R., Livingston, A. Berkland, C. & Dhar, P. (2016). Physiochemical properties of aluminum adjuvants elicit differing reorganization of phospholipid domains in model membranes. Molecular Pharmaceutics, 13(5), 1731-7.

Tima, S. Okonogi, S. Ampasavate, C. Pickens, C. Berkland, C. & Anuchapreeda, S. (2016). Potential cIBR-Conjugated PLGA Nanoparticles for Selective Targeting to Leukemic Cells. Journal of Pharmaceutical Sciences, 105(12), 3645-3657.

Fang, W. B., Yao, M. Brummer, G. Acevedo, D. Alhakamy, N. Berkland, C. & Cheng, N. (2016). Targeted gene silencing of CCL2 inhibits triple negative breast cancer progression by blocking cancer stem cell renewal and M2 macrophage recruitment. Oncotarget, 7(31), 49349-49367. DOI:10.18632/oncotarget.9885

Alhakamy, N. A., Ishiguro, S. Uppalapati, D. Berkland, C. J., & Tamura, M. (2016). AT2R Gene Delivered by Condensed Polylysine Complexes Attenuates Lewis Lung Carcinoma after Intravenous Injection or Intratracheal Spray. Molecular cancer therapeutics, 15(1), 209-18. DOI:10.1158/1535-7163.MCT-15-0448

Hartwell, B. L., Antunez, L. Sullivan, B. P., Thati, S. Sestak, J. O., & Berkland, C. (2015). Multivalent Nanomaterials: Learning from Vaccines and Progressing to Antigen-Specific Immunotherapies. Journal of Pharmaceutical Science, 104(2), 346-361.

Thati, S. Kuehl, C. Hartwell, B. Sestak, J. Siahaan, T. Forrest, L. & Berkland, C. (2015). Routes of Administration and Dose Optimization of Soluble Antigen Arrays in Mice with Experimental Autoimmune Encephalomyelitis. Journal of Pharmaceutical Science, 104(2), 714-721.

Beck, E. C., Lohman, B. L., Tabakh, D. B., Kieweg, S. L., Gehrke, S. H., Berkland, C. J., & Detamore, M. S. (2015). Enabling Surgical Placement of Hydrogels Through Achieving Paste-Like Rheological Behavior in Hydrogel Precursor Solutions. Annals of biomedical engineering, 43(10), 2569-76. DOI:10.1007/s10439-015-1277-8

Mohan, N. Gupta, V. Sridharan, B. P., Mellott, A. J., Easley, J. T., Palmer, R. H., Galbraith, R. A., Key, V. H., Berkland, C. J., & Detamore, M. S. (2015). Microsphere-based gradient implants for osteochondral regeneration: a long-term study in sheep. Regenerative medicine, 10(6), 709-28. DOI:10.2217/rme.15.38

Dennis, S. C., Berkland, C. J., Bonewald, L. F., & Detamore, M. S. (2015). Endochondral ossification for enhancing bone regeneration: converging native extracellular matrix biomaterials and developmental engineering in vivo. Tissue engineering. Part B, Reviews, 21(3), 247-66. DOI:10.1089/ten.TEB.2014.0419

Alhakamy, N. A., Elandaloussi, I. Ghazvini, S. Berkland, C. J., & Dhar, P. (2015). Effect of lipid headgroup charge and pH on the stability and membrane insertion potential of calcium condensed gene complexes. Langmuir : the ACS journal of surfaces and colloids, 31(14), 4232-45. DOI:10.1021/la504970n

Sutherland, A. J., Beck, E. C., Dennis, S. C., Converse, G. L., Hopkins, R. A., Berkland, C. J., & Detamore, M. S. (2015). Decellularized cartilage may be a chondroinductive material for osteochondral tissue engineering. PloS one, 10(5), e0121966. DOI:10.1371/journal.pone.0121966

Gupta, V. Mohan, N. Berkland, C. J., & Detamore, M. S. (2015). Microsphere-Based Scaffolds Carrying Opposing Gradients of Chondroitin Sulfate and Tricalcium Phosphate. Frontiers in Bioengineering and Biotechnology, 3, 96. DOI:10.3389/fbioe.2015.00096

Dormer, N. H., Berkland, C. J., & Singh, M. (2014). Monodispersed Microencapsulation Technology. In N. Vasisht, A. R Khare, & R. Sobel (Eds.), Microencapsulation in the Food Industry.

El-Gendy, N. Bailey, M. & Berkland, C. (2014). Particle Engineering Technologies for Pulmonary Drug Delivery. In H. Smyth & A. Hickey (Eds.), Controlled Release Science and Technology: Pulmonary Delivery (pp. 283-312).

Dennis, S. C., Bonewald, L. Berkland, C. & Detamore, M. S. (in press). Endochondral Ossification for Enhancing Bone Regeneration: Converging Native ECM Biomaterials and Developmental Engineering in vivo. Tissue Engineering Part B Reviews.

Sestak, J. Thati, S. Northrup, L. Mullins, M. Siahan, T. J., & Berkland, C. (2014). Co-Delivery of Antigen and an Immune Cell adhesion Inhibitor is Necessary for Efficacy of Soluble Antigen Arrays in Experimental Encephalomyelitis. Molecular Therapy - Methods & Clinical Development.

Baoum, A. A., Middaugh, C. R., & Berklund, C. (2014). DNA complexed with TAT peptide and condensed using calcium possesses unique structural features compared to PEI polyplexes. International Journal of Pharmaceutics, 465(2-Jan), 17-Nov.

Fakhari, A. Phan, Q. & Berkland, C. (2014). Hyaluronic acid colloidal gels as self-assembling elastic biomaterials. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 102(3), 612-618. DOI:10.1002/JBM.B.33041

Chittasupho, C. Sestak, J. Shannon, L. Siahaan, T. J., Vines, C. M., & Berkland, C. (2014). Hyaluronic acid graft polymers displaying peptide antigen modulate dendritic cell response in vitro. Molecular Pharmaceutics, 11(1), 367-373.

Kuehl, C. El-Gendy, N. & Berkland, C. (2014). NanoClusters Surface Area Allows Nanoparticle Dissolution with Microparticle Properties. Journal of Pharmaceutical Sciences, 103(6), 1787-1796.

Northrup, L. Sestak, J. O., Sullivan, B. P., Thati, S. Hartwell, B. L., Siahaan, T. J., Vines, C. M., & Berkland, C. (2014). Co-delivery of autoantigen and B7 pathway modulators suppresses experimental autoimmune encephalomyelitis. AAPS Journal, 16(6), 1204-13.

Sestak, J. O., Fakhari, A. Badawi, A. H., Siahaan, T. J., & Berkland, C. (2014). Structure, size, and solubility of antigen arrays determines efficacy in experimental autoimmune encephalomyelitis. AAPS Journal, 16(6), 1185-93.

Dennis, S. C., Detamore, M. S., Kieweg, S. L., & Berkland, C. J. (2014). Mapping glycosaminoglycan-hydroxyapatite colloidal gels as potential tissue defect fillers. Langmuir : the ACS journal of surfaces and colloids, 30(12), 3528-37. DOI:10.1021/la4041985

Fakhari, A. & Berkland, C. (2013). Applications and Emerging Trends of Hyaluronic Acid in Tissue Engineering, as a Dermal Filler, and in Osteoarthritis Treatment. Acta Biomaterialia, 9(7), 7081-7092.

Smaldone, G. Gonda, I. Mitchell, J. Usmani, O. Berkland, C. & Clark, A. (2013). Ask the experts: The benefits and challenges of pulmonary drug delivery. Therapeutic Delivery, 4(8), 9-Jan.

El-Gendy, N. A., Kaviratna, A. Berkland, C. J., & Dhar, P. (2013). Delivery and performance of surfactant replacement therapies to treat pulmonary disorders. Therapeutic Delivery, 4(8), 951-980.

Fakhari, A. Phan, Q. & Berkland, C. (2013). Hyaluronic acid nanoparticles titrate the viscoelastic properties of viscosupplements. Langmuir, 29(17), 5123-5131.

Wang, Q. Gu, Z. Jamal, S. Detamore, M. S., & Berkland, C. (2013). Hybrid Hydroxyapatite Nanoparticle Colloidal Gels are Injectable Fillers for Bone Tissue Engineering. Tissue Engineering: Part A, 19(23-24), 2586-2593.

Thaiboonrod, S. Berkland, C. Milani, A. H., Ulijn, R. & Saunders, B. R. (2013). Poly(vinylamine) Microgels: pH-Responsive Particles with High Primary Amine Contents. Soft Matter, 9, 3920-3930.

Sestak, J. Thati, S. Northrup, L. Mullins, M. Siahaan, T. J., & Berkland, C. (2013). Single-Step Grafting of Aminooxy-Peptides to Hyaluronan: A Simple Approach to Multifunctional Therapeutics for Experimental Autoimmune Encephalomyelitis. Journal of Controlled Release, 168(3), 334-340.

Suekama, T. C., Aziz, V. Mohammadi, Z. Berkland, C. & Gehrke, S. H. (2013). Synthesis and characterization of poly (N?vinyl formamide) hydrogels � A potential alternative to polyacrylamide hydrogels. Journal of Polymer Science Part A: Polymer Chemistry, 51, 435-445.

Alhakamy, N. A., Kaviratna, A. Berkland, C. J., & Dhar, P. (2013). Dynamic measurements of membrane insertion potential of synthetic cell penetrating peptides. Langmuir : the ACS journal of surfaces and colloids, 29(49), 15336-49. DOI:10.1021/la403370p

Dormer, N. H., Gupta, V. Scurto, A. M., Berkland, C. J., & Detamore, M. S. (2013). Effect of different sintering methods on bioactivity and release of proteins from PLGA microspheres. Materials science & engineering. C, Materials for biological applications, 33(7), 4343-51. DOI:10.1016/j.msec.2013.06.026

Alhakamy, N. A., Nigatu, A. S., Berkland, C. J., & Ramsey, J. D. (2013). Noncovalently associated cell-penetrating peptides for gene delivery applications. Therapeutic delivery, 4(6), 741-57. DOI:10.4155/tde.13.44

Alhakamy, N. A., & Berkland, C. J. (2013). Polyarginine molecular weight determines transfection efficiency of calcium condensed complexes. Molecular pharmaceutics, 10(5), 1940-8. DOI:10.1021/mp3007117

Jeon, J. H., Bhamidipati, M. Sridharan, B. Scurto, A. M., Berkland, C. J., & Detamore, M. S. (2013). Tailoring of processing parameters for sintering microsphere-based scaffolds with dense-phase carbon dioxide. Journal of biomedical materials research. Part B, Applied biomaterials, 101(2), 330-7. DOI:10.1002/jbm.b.32843

Baoum, A. Ovachenkov, D. & Berkland, C. (2012). Calcium Condensed Cell-Penetrating Peptide Complexes Offer Highly Efficient, Low Toxicity Gene Silencing. International Journal of Pharmaceutics, 427(1), 134-142.

Bailey, M. M., Kline, S. R., Anderson, M. D., Staymates, J. L., & Berkland, C. (2012). Chemically Modifiable Fluorinated Copolymer Nanoparticles for 19F-MRI Contrast Enhancement. Journal of Applied Polymer Science, 126(4), 1218-1227.

El-Gendy, N. Selvam, P. Soni, P. & Berkland, C. (2012). Development of Budesonide NanoCluster Dry Powder Aerosols: Formulation and Stability. Journal of Pharmaceutical Sciences, 101(9), 3445-3455.

El-Gendy, N. Selvam, P. Soni, P. & Berkland, C. (2012). Development of Budesonide NanoCluster Dry Powder Aerosols: Preformulation. Journal of Pharmaceutical Sciences, 101(9), 3434-3444.

El-Gendy, N. Selvam, P. Soni, P. & Berkland, C. (2012). Development of Budesonide NanoCluster Dry Powder Aerosols: Processing. Journal of Pharmaceutical Sciences, 101(9), 3425-3433.

Kawabata, A. Baoum, A. Ohta, N. Jacquez, S. Seo, G. M., Berkland, C. & Tamura, M. (2012). Intratracheal administration of a nanoparticle-based therapy with the angiotensin II type 2 receptor gene attenuates lung cancer growth. Cancer Research, 72(8), 2057-2067.

Bagby, T. R., Duan, S. Cai, S. Thati, S. Berkland, C. Aires, D. & Forrest, M. L. (2012). Lymphatic trafficking kinetics and near-infrared imaging using star polymer architectures with controlled anionic character. European Journal of Pharmaceutical Sciences, 47(1), 287-294.

Pornputtapitak, W. El-Gendy, N. & Berkland, C. (2012). Nanocluster budesonide formulations enhance drug delivery through endotracheal tubes. Journal of Pharmaceutical Sciences, 101(3), 1063-1072.

Pornputtapitak, W. El-Gendy, N. Mermis, J. O�Brien-Ladner, A. & Berkland, C. (2012). Nanocluster budesonide formulations enhance drug delivery through endotracheal tubes. Journal of Pharmaceutical Sciences, 101(3), 1063-1072.

Phongpradist, R. Chiampanichayakul, S. Tima, S. Siahaan, T. J., Berkland, C. Anuchapreeda, S. & Ampasavate, C. (2012). Potential cIBR-Conjugated PLGA Nanoparticles for Selective Targeting to Leukemic Cells. World Academy of Science, Engineering and Technology, 6(6), 234-242.

Yang, J. Xie, S. X., Huang, Y. Ling, M. Liu, J. Ran, Y. Wang, Y. Thrasher, J. B., Berkland, C. & Li, B. (2012). Prostate-targeted biodegradable nanoparticles loaded with androgen receptor silencing constructs eradicate xenograft tumors in mice. Nanomedicine, 7(9), 1297-1309.

Buyuktimkin, B. Wang, Q. Kiptoo, P. Stewart, J. Berkland, C. & Siahaan, T. (2012). Vaccine-like controlled-release delivery of an immunomodulating peptide to treat experimental autoimmune encephalomyelitis. Molecular Pharmaceutics, 9(4), 979-985.

Dormer, N. H., Qiu, Y. Lydick, A. M., Allen, N. D., Mohan, N. Berkland, C. J., & Detamore, M. S. (2012). Osteogenic differentiation of human bone marrow stromal cells in hydroxyapatite-loaded microsphere-based scaffolds. Tissue engineering. Part A, 18(8-Jul), 757-67. DOI:10.1089/ten.TEA.2011.0176

Dormer, N. H., Singh, M. Zhao, L. Mohan, N. Berkland, C. J., & Detamore, M. S. (2012). Osteochondral interface regeneration of the rabbit knee with macroscopic gradients of bioactive signals. Journal of biomedical materials research. Part A, 100(1), 162-70. DOI:10.1002/jbm.a.33225

El-Gendy, N. Bailey, M. & Berkland, C. (2011). Particle Engineering Technologies for Pulmonary Drug Delivery. In H. Smyth & A. Hickey (Eds.), Controlled Release Science and Technology: Pulmonary Delivery (pp. 283-312).

Berkland, C. (2011). Engineering particles and colloids for pharmaceutical and biomaterial applications. In Progress in Drug Delivery Systems XX, Shizuoka, Japan (pp. 4-Jan).

Chittasupho, C. Siahaan, T. J., Vines, C. M., & Berkland, C. (2011). Autoimmune therapies targeting costimulation and emerging trends in strategies using multivalent therapeutics. Therapeutic Delivery, 2(7), 873-889.

Baoum, A. & Berkland, C. (2011). Calcium Condensation of DNA Complexed with Cell-Penetrating Peptides Offers Efficient, Noncytotoxic Gene Delivery. Journal of Pharmaceutical Sciences, 100(5), 1637-1642.

Khondee, S. Baoum, A. Siahaan, T. J., & Berkland, C. (2011). Calcium Condensed LABL-TAT Complexes Effectively Target Gene Delivery to ICAM-1 Expressing Cells. Molecular Pharmaceutics, 8(3), 788-798.

Fakhari, A. Baoum, A. Siahaan, T. J., Le, K. B., & Berkland, C. (2011). Controlling ligand surface density optimizes nanoparticle binding to ICAM-1. Journal of Pharmaceutical Sciences, 100(3), 1045-1056.

Mohammadi, Z. Xie, S. Peltier, E. Veisi, M. & Berkland, C. (2011). Enhancing the selectivity of an iron binding hydrogel. European Polymer Journal, European Polymer Journal, 47(7), 1485-1488.

El-Gendy, N. Pornputtapitak, W. & Berkland, C. (2011). Nanoparticle agglomerates of fluticasone propionate in combination with albuterol sulfate as dry powder aerosols. European Journal of Pharmaceutics, 44(4), 522-533.

Chittasupho, C. Shannon, L. Krise, J. P., Siahaan, T. J., Vines, C. M., & Berkland, C. (2011). Nanoparticles targeting dendritic cell surface molecules effectively block T cell conjugation and shift response. ACS Nano, 5(3), 1693-1702.

Khondee, S. Olsen, C. Zeng, Y. Middaugh, C. R., & Berkland, C. (2011). Non-covalent PEGylation by polyanion complexation as a means to stabilize keratinocyte growth factor-2 (KGF-2). Biomacromolecules, 12(11), 3880-3894.

Wang, Q. Jamal, S. Detamore, M. S., & Berkland, C. (2011). PLGA-chitosan/PLGA-alginate nanoparticle blends as biodegradable colloidal gels for seeding human umbilical cord mesenchymal stem cells. Journal of Biomedical Materials Research, Part A 96(3), 520-527.

Shang, Q. Wang, X. Apley, M. Kukanich, S. B., & Berkland, C. (2011). PPF Microsphere Depot Sustains NSAID Blood Levels with Infusion-Like Kinetics without 'Burst'. Journal of Veterinary Pharmacology and Therapeutics, 35(3), 231-238.

Mohammadi, Z. Xie, S. Allison, G. Gehrke, S. & Berkland, C. (2011). Siderophore-Mimetic Hydrogel for Iron Chelation Therapy. Journal of Applied Polymer Science, 121(3), 1384-1392.

Mohan, N. Dormer, N. H., Caldwell, K. L., Key, V. H., Berkland, C. J., & Detamore, M. S. (2011). Continuous gradients of material composition and growth factors for effective regeneration of the osteochondral interface. Tissue engineering. Part A, 17(21-22), 2845-55. DOI:10.1089/ten.tea.2011.0135

Lazebnik, M. Singh, M. Glatt, P. Friis, L. A., Berkland, C. J., & Detamore, M. S. (2011). Biomimetic method for combining the nucleus pulposus and annulus fibrosus for intervertebral disc tissue engineering. Journal of tissue engineering and regenerative medicine, 5(8), e179-87. DOI:10.1002/term.412

Dormer, N. H., Busaidy, K. Berkland, C. J., & Detamore, M. S. (2011). Osteochondral interface regeneration of rabbit mandibular condyle with bioactive signal gradients. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 69(6), e50-7. DOI:10.1016/j.joms.2010.12.049

Bailey, M. & Berkland, C. (2010). Modified release delivery systems. In M. Morishita & K. Park (Eds.), Biodrug Delivery Systems (Vol. 194, pp. 234-247).

Berkland, C. Laurence, G. Lermer, S. Soni, P. & Crowley, M. (2010). An overview of nanocluster powder formulation technology. Pharmaceutical Technology, 34(10), 72-74,76,78.

Baoum, A. Dhillon, N. Buch, S. & Berkland, C. (2010). Cationic surface modification of PLG nanoparticles offers sustained gene delivery to pulmonary epithelial cells. Journal of Pharmaceutical Sciences, 99(5), 2413-2422. DOI:10.1002/jps.21994

Chittasupho, C. Manikwar, P. Krise, J. P., Siahaan, T. & Berkland, C. (2010). cIBR effectively targets nanoparticles to LFA-1 on acute lymphoblastic T cells. Molecular Pharmaceutics, 7(1), 146-155.

El-Gendy, N. Aillon, K. & Berkland, C. (2010). Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. International Journal of Pharmaceutics, 391(2-Jan), 305-312.

Bailey, M. M., Mahoney, C. M., Dempah, E. Davis, J. Becker, M. L., Khondee, S. Munson, E. J., & Berkland, C. (2010). Fluorinated Copolymer Nanoparticles for Multimodal Imaging Applications. Macromolecule Rapid Communications, 31(1), 87-92.

Wang, Q. Wang, J. Lu, Q. Detamore, M. S., & Berkland, C. (2010). Injectable PLGA based colloidal gels for zero-order dexamethasone release in cranial defects. Biomaterials, 31(18), 4980-4986.

Aillon, K. L., El-Gendy, N. Dennis, C. Norenberg, J. P., McDonald, J. & Berkland, C. (2010). Iodinated NanoClusters as an inhaled computed tomography contrast agent for lung visualization. Molecular Pharmaceutics, 7(4), 1274-1282.

Phongpradist, R. Chittasupho, C. Okonogi, S. Siahaan, T. Anuchapreeda, S. Ampasavate, C. & Berkland, C. (2010). LFA-1 on leukemic cells as a target for therapy or drug delivery. Current Pharmaceutical Design, 16(21), 2321-2330.

Khondee, S. Yakovleva, T. & Berkland, C. (2010). Low charge polyvinylamine nanogels offer sustained, low-level gene expression. Journal of Applied Polymer Science, 118(4), 1921-1932.

Mohammadi, Z. Wang, X. & Berkland, C. (2010). Magnetic Polyvinylamine Nanoparticles by In Situ Precipitation Reaction. The Journal of Polymer Science Part A: Polymer Chemistry, 7(4), 1274-1282.

Singh, M. Sandhu, B. Scurto, A. Berkland, C. & Detamore, M. S. (2010). Microsphere-Based Scaffolds for Cartilage Tissue Engineering: Using Subcritical CO2 as a Sintering Agent. Acta Biomaterialia, 6, 137-143.

Berkland, C. (2010). Next Steps for Pharmaceutical Nanotechnology. Journal of Pharmaceutical Innovation, 5(3), 70-71.

Pickel, L. Matsuzuka, T. Doi, C. Ayuzawa, R. Maurya, D. K., Xie, S. Berkland, C. & Tamura, M. (2010). Overexpression of angiotensin II type 2 receptor gene induces cell death in lung adenocarcinoma cells. Cancer Biology & Therapy, 9(4).

Staymates, M. Fletcher, R. Staymates, J. Gillen, G. & Berkland, C. (2010). Production and characterization of polymer microspheres containing trace explosives using precision particle fabrication technology. Journal of Microencapsulation, 27(5), 426-435.

Williams, J. S., Huang, H. H., Kover, K. Moore, W. Berkland, C. Singh, M. Smirnova, I. V., Macgregor, R. & Stehno-Bittel, L. (2010). Reduction of diffusion barriers in isolated rat islets improves survival, but not insulin secretion or transplantation outcome. Organogenesis, 6(2), 115-124.

Bailey, M. & Berkland, C. (2010). Research Spotlight: Therapeutic Particles and Biomaterials Technology Laboratory at The University of Kansas. Therapeutic Delivery, 1(1), 29-35.

Singh, M. Dormer, N. H., Detamore, M. S., & Berkland, C. (2010). Three-dimensional Macroscopic Scaffolds With a Gradient in Stiffness for Functional Regeneration of Interfacial Tissues. Journal of Biomedical Materials Research, Part A 94(3), 870-876.

Xie, Y. Aillon, K. L., Cai, S. Christian, J. M., Davies, N. M., Berkland, C. J., & Forrest, M. L. (2010). Pulmonary delivery of cisplatin-hyaluronan conjugates via endotracheal instillation for the treatment of lung cancer. International journal of pharmaceutics, 392(2-Jan), 156-63. DOI:10.1016/j.ijpharm.2010.03.058

Xie, Y. Aillon, K. L., Cai, S. Christian, J. M., Davies, N. M., Berkland, C. J., & Forrest, M. L. (2010). Pulmonary delivery of cisplatin-hyaluronan conjugates via endotracheal instillation for the treatment of lung cancer. International journal of pharmaceutics, 392(2-Jan), 156-63. DOI:10.1016/j.ijpharm.2010.03.058

Dormer, N. H., Berkland, C. J., & Detamore, M. S. (2010). Emerging techniques in stratified designs and continuous gradients for tissue engineering of interfaces. Annals of biomedical engineering, 38(6), 2121-41. DOI:10.1007/s10439-010-0033-3

Dormer, N. H., Berkland, C. J., & Detamore, M. S. (2010). Emerging techniques in stratified designs and continuous gradients for tissue engineering of interfaces. Annals of biomedical engineering, 38(6), 2121-41. DOI:10.1007/s10439-010-0033-3

Dormer, N. H., Singh, M. Wang, L. Berkland, C. J., & Detamore, M. S. (2010). Osteochondral interface tissue engineering using macroscopic gradients of bioactive signals. Annals of biomedical engineering, 38(6), 2167-82. DOI:10.1007/s10439-010-0028-0

Williams, S. J., Wang, Q. MacGregor, R. R., Siahaan, T. J., Stehno-Bittel, L. & Berkland, C. (2009). Adhesion of Pancreatic Beta Cells to Biopolymer Films. Biopolymers, 91(8), 676-685.

El-Gendy, N. Gorman, E. Munson, E. & Berkland, C. (2009). Budesonide Nanoparticle Agglomerates as Dry Powder Aerosols with Rapid Dissolution. Journal of Pharmaceutical Sciences, 98(8), 2731-2746.

El-Gendy, N. & Berkland, C. (2009). Combination chemotherapeutic dry powder aerosols via controlled nanoparticle agglomeration. Pharmaceutical Research, 26(7), 1752-1763.

Johnson, S. J., Trejo, J. Veisi, M. Willhite, G. P., Liang, J. T., & Berkland, C. (2009). Effects of divalent cations, seawater, and formation brine on positively charged polyethylenimine/dextran sulfate/chromium(III) polyelectrolyte complexes and partially hydrolyzed polyacrylamide/chromium(III) gelation. Journal of Applied Polymer Science, 115(2), 1008-1014. DOI:10.1002/app.31052

Mohammadi, Z. Cole, A. & Berkland, C. (2009). In situ synthesis of iron oxide within polyvinylamine nanoparticle reactors. The Journal of Physical Chemistry Part C, 113(18), 7652-7658.

Plumley, C. J., Gorman, E. Bybee, C. Munson, E. & Berkland, C. (2009). Nifedipine Nanoparticle Agglomeration as a Dry Powder Aerosol Formulation Strategy. International Journal of Pharmaceutics, 369(2-Jan), 136-143.

Baoum, A. Xie, S. & Berkland, C. (2009). �Soft� Calcium Crosslinks Enable Highly Efficient Gene Transfection Using TAT Peptide. Pharmaceutical Research, 26(12), 2619-2629.

Nune, S. K., Gunda, P. Thallapally, P. K., Lin, Y. Y., Forrest, M. L., & Berkland, C. J. (2009). Nanoparticles for biomedical imaging. Expert opinion on drug delivery, 6(11), 1175-94. DOI:10.1517/17425240903229031

Nune, S. K., Gunda, P. Thallapally, P. K., Lin, Y. Y., Forrest, M. L., & Berkland, C. J. (2009). Nanoparticles for biomedical imaging. Expert opinion on drug delivery, 6(11), 1175-94. DOI:10.1517/17425240903229031

Aillon, K. L., Xie, Y. El-Gendy, N. Berkland, C. J., & Forrest, M. L. (2009). Effects of nanomaterial physicochemical properties on in vivo toxicity. Advanced drug delivery reviews, 61(6), 457-66. DOI:10.1016/j.addr.2009.03.010

Aillon, K. L., Xie, Y. El-Gendy, N. Berkland, C. J., & Forrest, M. L. (2009). Effects of nanomaterial physicochemical properties on in vivo toxicity. Advanced drug delivery reviews, 61(6), 457-66. DOI:10.1016/j.addr.2009.03.010

Chittasupho, C. Xie, S. X., Baoum, A. Yakovleva, T. Siahaan, T. J., & Berkland, C. J. (2009). ICAM-1 targeting of doxorubicin-loaded PLGA nanoparticles to lung epithelial cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 37(2), 141-50. DOI:10.1016/j.ejps.2009.02.008

Chittasupho, C. Xie, S. X., Baoum, A. Yakovleva, T. Siahaan, T. J., & Berkland, C. J. (2009). ICAM-1 targeting of doxorubicin-loaded PLGA nanoparticles to lung epithelial cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 37(2), 141-50. DOI:10.1016/j.ejps.2009.02.008

Bailey, M. M., & Berkland, C. J. (2009). Nanoparticle formulations in pulmonary drug delivery. Medicinal research reviews, 29(1), 196-212. DOI:10.1002/med.20140

Wang, Q. Wang, L. Detamore, M. & Berkland, C. (2008). Biodegradable Colloidal Gels as Moldable Tissue Engineering Scaffolds. Advanced Materials, 20(2), 236-239.

Huang, M. & Berkland, C. (2008). Controlled Release of Repifermin� from Polyelectrolyte Complexes Stimulates Endothelial Cell Proliferation. Journal of Pharmaceutical Sciences, 98(1), 268-280. DOI:10.1002/jps.21412

Cordova, M. Cheng, M. Trejo, J. Johnson, S. J., Willhite, G. P., Liang, J. T., & Berkland, C. (2008). Delayed HPAM Gelation via Transient Sequestration of Chromium in Polyelectrolyte Complex Nanoparticles. Macromolecules, 41(12), 4398-4404.

Singh, M. Morris, C. P., Ellis, R. Detamore, M. S., & Berkland, C. (2008). Microsphere-Based Seamless Scaffolds Containing Macroscopic Gradients of Encapsulated Factors for Tissue Engineering. Tissue Engineering Part C, 14(4), 299-309.

Huang, M. Huang, Z. L., Bilgen, M. & Berkland, C. (2008). MRI Contrast-Enhanced Polyelectrolyte Complexes. Nanomedicine, 4(1), 30-40.

Peek, L. J., Middaugh, C. R., & Berkland, C. (2008). Nanotechnology in Vaccine Delivery. Advanced Drug Delivery Reviews, 60(8), 915-928.

Peek, L. J., Roberts, L. & Berkland, C. (2008). PLG Nanoparticle Agglomerates as Carriers in Dry Powder Aerosol Formulation of Proteins. Langmuir, 24(17), 9775-9783.

Zhang, N. Chittasupho, C. Duangrat, C. Siahaan, T. & Berkland, C. (2008). PLGA Nanoparticle-Peptide Conjugate Effectively Targets Intercellular Cell-Adhesion Molecule-1. Bioconjugate Chemistry, 19(1), 145-152.

Shi, L. Khondee, S. Linz, T. H., & Berkland, C. (2008). Poly(N-vinylformamide) Nanogels Capable of pH-Sensitive Protein Release. Macromolecules, 41(17), 6546-6554.

Bailey, M. Gorman, E. Munson, E. & Berkland, C. (2008). Pure Insulin Nanoparticle Agglomerates for Pulmonary Delivery. Langmuir, 24(23), 13641-13620.

Singh, M. Berkland, C. & Detamore, M. S. (2008). Strategies and Applications for Incorporating Physical and Chemical Signal Gradients in Tissue Engineering. Tissue Engineering Part B, 14(4), 341-366.

Shi, L. & Berkland, C. (2007). Acid-Labile Polyvinylamine Micro- and Nanogel Capsules. Macromolecules, 40(13), 4635-4643.

Shi, L. Plumley, C. J., & Berkland, C. (2007). Biodegradable Nanoparticle Flocculates for Dry Powder Aerosol Formulation. Langmuir, 23(22), 10897-10901.

Berkland, C. Pollauf, E. J., Raman, C. Silverman, R. Kim, K. & Pack, D. W. (2007). Macromolecule release from monodisperse PLG microspheres: control of release rates and investigation of release mechanism. Journal of Pharmaceutical Sciences, 95(5), 1176-1191.

Berkland, C. Pollauf, E. J., Varde, N. Pack, D. W., & Kim, K. (2007). Monodisperse liquid-filled biodegradable microcapsules. Pharmaceutical Research, 24(5), 1007-1013.

Arnold, M. M., Gorman, E. M., Scheiber, L. J., Munson, E. J., & Berkland, C. (2007). NanoCipro Encapsulation in Monodisperse Large Porous PLGA Microparticles. Journal of Controlled Release, 120, 100-109.

Huang, M. Vitharana, S. N., Peek, L. J., Coop, T. & Berkland, C. (2007). Polyelectrolyte Complexes Stabilize and Controllably Release VEGF. Biomacromolecules, 8(5), 1607-1614.

Dunehoo, A. L., Anderson, M. Majumdar, S. Kobayashi, N. Berkland, C. & Siahaan, T. J. (2006). Cell adhesion molecules for targeted drug delivery. Journal of Pharmaceutical Sciences, 96(1), 234. DOI:10.1002/jps.20791

Shi, L. & Berkland, C. (2006). pH-Triggered Dispersion of Nanoparticle Clusters. Advanced Materials, 18(17), 2315-2319.

Pollauf, E. J., Berkland, C. Kim, K. & Pack, D. W. (2005). In vitro degradation of polyanhydride/polyester core-shell double-wall microspheres. International Journal of Pharmaceutics, 301(2-Jan), 294-303.

Raman, C. Berkland, C. Kim, K. & Pack, D. W. (2005). Modeling small-molecule release from PLG microspheres: effects of polymer degradation and non-uniform drug distribution. Journal of Controlled Release, 103(1), 149-158.

Berkland, C. Kim, K. & Pack, D. W. (2004). Three-month, zero-order piroxicam release from monodispersed double-walled microspheres of controlled shell thickness. (4th ed., Vol. 70A, pp. 576-584). In Journal of Biomedical Materials Research, DOI:10.1002/jbm.a.30114

Berkland, C. Kim, K. & Pack, D. W. (2004). Controlling Surface Nano-Structure using Flow-Limited Field-Injection Electrostatic Spraying (FFESS) of Poly-(D,L-lactide-co-glycolide). Biomaterials, 25(25), 5649-5658.

Berkland, C. Kipper, M. J., Narasimhan, B. Kim, K. & Pack, D. W. (2004). Microsphere Size, Precipitation Kinetics, and Drug Distribution Control Drug Release from Biodegradable Polyanhydride Microspheres. Journal of Controlled Release, 94(1), 129-141.

Berkland, C. Kim, K. & Pack, D. W. (2004). Uniform double-walled polymer microspheres of controllable shell thickness. Journal of Controlled Release, 96(1), 101-111.

Berkland, C. Kim, K. & Pack, D. W. (2003). PLG microsphere size controls drug release rate through several competing factors. Pharmaceutical Research, 20(7), 1055-1062.

Pack, D. W., Berkland, C. Varde, N. & Kim, K. (2002). Precision polymer microshells for controlled-release drug delivery. In 223rd ACS National Meeting extended abstract.

Berkland, C. King, M. Cox, A. Kim, K. & Pack, D. W. (2002). Precise control of PLG microsphere size provides enhanced control of drug release rate. Journal of Controlled Release, 82(1), 137-147.

Berkland, C. Kim, K. & Pack, D. W. (2001). Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions. Journal of Controlled Release, 73(1), 59-74.

Berkland, C. Kim, K. & Pack, D. (2000). Fabrication of PLGA microspheres with precisely controlled, homogeneous size distribution. In Proceedings of the International Symposium on Controlled Release of Bioactive Materials (pp. 1130-1131).

Selected Presentations

.

Selected Grants

Selected Awards & Honors

Education

  • Post Doc Chemical and Biomolecular Engineering - University of Illinois, Urbana 2004
  • PhD Chemical and Biomolecular Engineering - University of Illinois, Urbana May 2003
  • MS Chemical Engineering - University of Illinois, Urbana May 2001
  • BS Chemical Engineering Iowa State University, Ames Dec 1998

Research

In recent history, through the merger of engineering and biological sciences, biotechnology has pressed toward improving methods for regenerating tissues, developing biosensors, and effectively delivering therapeutic agents. Accomplishing such tasks requires specifically designing biomedical or drug delivery devices that possess the required physicochemical properties. Our lab focuses on developing precision engineering technologies at the macro- to molecular scale for novel or improved biomedical and drug delivery devices.

Precision Particles

Precisely sized micro- or nanoparticles offer several advantages over conventional particulate drug formulations. Our previous work has established uniform biodegradable particles as a means to control and define the release profile of drugs over time. In addition, specifically modulating microsphere size offers an attractive means to improve drug administration while controlling release. For example, the deep lung can be effectively reached by 1-3 micron particles while 10-20 micron particles can embolize a tumor bed for localized delivery of chemotherapeutics. Finally, the design of microcapsules utilizing a degradable polymeric shell of controlled thickness may provide a novel platform for the development of pulsatile drug release profiles as desired for vaccine formulations

Precision Tissue Scaffolds

The properties of tissue scaffolds, such as overall size/shape, degradability, compression strength, porosity, and surface structure are difficult to control using conventional techniques and need to be specifically tuned depending on the medical application. By combining various device fabrication techniques such as soft lithography, precision particle fabrication, and electrostatic spraying, polymeric devices exhibiting precision macro-, micro-, and nano-structure can be produced. Utilizing these techniques in combination provides biomedical devices exhibiting controlled properties including biodegradable tissue scaffolds with periodic structure.

Peer Reviewed Publications

L. Shi and C. Berkland pH-Triggered Dispersion of Nanoparticle Clusters. Advanced Materialsin press.

EJ. Pollauf, C. Berkland, K. Kim, and D.W. Pack (2005) In vitro degradation of polyanhydride/polyester core-shell double-wall microspheres International Journal of Pharmaceutics, 301(1-2):294-303.

C. Raman, C. Berkland, K. Kim, and D.W. Pack (2005) Modeling small-molecule release from PLG microspheres: effects of polymer degradation and nonuniform drug distribution Journal of Controlled Release, 103(1):149-158

C. Berkland, K. Kim, and D.W. Pack (2004) Controlling double-walled microcapsule shell thickness offers modulated piroxicam release Journal of Biomedical Materials Research 70A(4):576-584

C. Berkland, K. Kim, and D.W. Pack (2004) Uniform double-walled polymer microspheres of controllable shell thickness Journal of Controlled Release, 96(1):101-111

C. Berkland, K. Kim, and D.W. Pack (2004) Controlling Surface Nano-Structure using Flow-Limited Field-Injection Electrostatic Spraying (FFESS) of Poly-(D,L-lactide-co-glycolide). Biomaterials, 25(25):5649-58

C. Berkland, M.J. Kipper, B. Narasimhan, K. Kim, and D.W. Pack (2004) Microsphere Size, Precipitation Kinetics, and Drug Distribution Control Drug Release from Biodegradable Polyanhydride Microspheres. Journal of Controlled Release, 94(1):129-141

C. Berkland, K. Kim, and D.W. Pack (2004)Precision polymer microparticles for controlled-release drug delivery. ACS Symposium Series, 879:197-213

C. Berkland, K. Kim, and D.W. Pack (2003) PLG microsphere size controls drug release rate through several competing factors. Pharmaceutical Research, 20(7):1055-1062

C. Berkland, M. King, A. Cox, K. Kim, and D.W. Pack (2002) Precise control of PLG microsphere size provides enhanced control of drug release rate. Journal of Controlled Release, 82(1):137-147

C. Berkland, K. Kim, and D.W. Pack (2001) Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions. Journal of Controlled Release, 73(1):59-74


Upcoming Events and Deadlines

Sunday, April 14th - GEA5K | Starts at 8am | 2101 Constant Ave 

Friday, May 3rd - Paul Willhite's Retirement Celebration | 6-8pm | Beren Petroleum Conference Center

Saturday, May 4th - Annual Departmental Awards Banquet | 5:30 - 8:30pm | KU Memorial Union's Ballroom

Saturday, May 18th - School of Engineering Recognition Ceremony | starts at 8am | Allen Fieldhouse


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