Brandon J. DeKosky
School of Engineering - Pharmaceutical Chemistry, Chemical & Petroleum EngineeringEducation
Ph.D., Chemical Engineering, University of Texas at Austin
B.S., Chemical Engineering, University of Kansas
Selected Publications
Duan, H. Chen, X. Boyington, J. C., Cheng, C. Zhang, Y. Jafari, A. J., Stephens, T. Tsybovsky, Y. Kalyuzhniy, O. Menis, S. Nason, M. C., Normandin, E. Mukhamedova, M. DeKosky, B. J., Wells, L. Schief, W. R., Tian, M. Alt, F. Kwong, P. D., & Mascola, J. R. (2018). Glycan-masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies. Immunity. DOI:10.1016/j.immuni.2018.07.005
Wang, B. DeKosky, B. J., Timm, M. R., Lee, J. Normandin, E. Misasi, J. Kong, R. McDaniel, J. R., Delidakis, G. Leigh, K. E., Niezold, T. Choi, C. W., Viox, E. G., Fahad, A. Cagigi, A. Ploquin, A. Leung, K. Yang, E. S., Kong, W. P., Voss, W. N., Schmidt, A. G., Moody, M. A., Ambrozak, D. R., Henry, A. R., Laboune, F. Ledgerwood, J. E., Graham, B. S., Connors, M. Douek, D. C., Sullivan, N. J., Ellington, A. D., Mascola, J. R., & Georgiou, G. (2018). Functional interrogation and mining of natively paired human VH:VL antibody repertoires. Nature biotechnology. DOI:10.1038/nbt.4052
DeKosky, B. J. (2017). Decoding the Antibody Repertoire: High Throughput Sequencing of Multiple Transcripts from Single B Cells, Springer International Publishing.
Kwong, P. D., Chuang, G. Y., DeKosky, B. J., Gindin, T. Georgiev, I. S., Lemmin, T. Schramm, C. A., Sheng, Z. Soto, C. Yang, A. S., Mascola, J. R., & Shapiro, L. (2017). Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1. Immunological reviews, 275(1), 108-128. DOI:10.1111/imr.12480
Lau, D. Lan, L. Y., Andrews, S. F., Henry, C. Rojas, K. T., Neu, K. E., Huang, M. Huang, Y. DeKosky, B. Palm, A. E., Ippolito, G. C., Georgiou, G. & Wilson, P. C. (2017). Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation. Science immunology, 2(7). DOI:10.1126/sciimmunol.aai8153
Lee, J. Boutz, D. R., Chromikova, V. Joyce, M. G., Vollmers, C. Leung, K. Horton, A. P., DeKosky, B. J., Lee, C. H., Lavinder, J. J., Murrin, E. M., Chrysostomou, C. Hoi, K. H., Tsybovsky, Y. Thomas, P. V., Druz, A. Zhang, B. Zhang, Y. Wang, L. Kong, W. P., Park, D. Popova, L. I., Dekker, C. L., Davis, M. M., Carter, C. E., Ross, T. M., Ellington, A. D., Wilson, P. C., Marcotte, E. M., Mascola, J. R., Ippolito, G. C., Krammer, F. Quake, S. R., Kwong, P. D., & Georgiou, G. (2016). Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination. Nature medicine, 22(12), 1456-1464. DOI:10.1038/nm.4224
Tian, M. Cheng, C. Chen, X. Duan, H. Cheng, H. L., Dao, M. Sheng, Z. Kimble, M. Wang, L. Lin, S. Schmidt, S. D., Du, Z. Joyce, M. G., Chen, Y. DeKosky, B. J., Chen, Y. Normandin, E. Cantor, E. Chen, R. E., Doria-Rose, N. A., Zhang, Y. Shi, W. Kong, W. P., Choe, M. Henry, A. R., Laboune, F. Georgiev, I. S., Huang, P. Y., Jain, S. McGuire, A. T., Georgeson, E. Menis, S. Douek, D. C., Schief, W. R., Stamatatos, L. Kwong, P. D., Shapiro, L. Haynes, B. F., Mascola, J. R., & Alt, F. W. (2016). Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires. Cell, 166(6), 1471-1484.e18. DOI:10.1016/j.cell.2016.07.029
DeKosky, B. J., Lungu, O. I., Park, D. Johnson, E. L., Charab, W. Chrysostomou, C. Kuroda, D. Ellington, A. D., Ippolito, G. C., Gray, J. J., & Georgiou, G. (2016). Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires. Proceedings of the National Academy of Sciences of the United States of America, 113(19), E2636-45. DOI:10.1073/pnas.1525510113
Murzabaev, M. Kojima, T. Mizoguchi, T. Kobayashi, I. DeKosky, B. J., Georgiou, G. & Nakano, H. (2016). Handmade microfluidic device for biochemical applications in emulsion. Journal of bioscience and bioengineering, 121(4), 471-6. DOI:10.1016/j.jbiosc.2015.08.001
McDaniel, J. R., DeKosky, B. J., Tanno, H. Ellington, A. D., & Georgiou, G. (2016). Ultra-high-throughput sequencing of the immune receptor repertoire from millions of lymphocytes. Nature protocols, 11(3), 429-42. DOI:10.1038/nprot.2016.024
Gorman, J. Soto, C. Yang, M. M., Davenport, T. M., Guttman, M. Bailer, R. T., Chambers, M. Chuang, G. Y., DeKosky, B. J., Doria-Rose, N. A., Druz, A. Ernandes, M. J., Georgiev, I. S., Jarosinski, M. C., Joyce, M. G., Lemmin, T. M., Leung, S. Louder, M. K., McDaniel, J. R., Narpala, S. Pancera, M. Stuckey, J. Wu, X. Yang, Y. Zhang, B. Zhou, T. Mullikin, J. C., Baxa, U. Georgiou, G. McDermott, A. B., Bonsignori, M. Haynes, B. F., Moore, P. L., Morris, L. Lee, K. K., Shapiro, L. Mascola, J. R., & Kwong, P. D. (2016). Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design. Nature structural & molecular biology, 23(1), 81-90. DOI:10.1038/nsmb.3144
Wang, B. Kluwe, C. A., Lungu, O. I., DeKosky, B. J., Kerr, S. A., Johnson, E. L., Jung, J. Rezigh, A. B., Carroll, S. M., Reyes, A. N., Bentz, J. R., Villanueva, I. Altman, A. L., Davey, R. A., Ellington, A. D., & Georgiou, G. (2015). Facile Discovery of a Diverse Panel of Anti-Ebola Virus Antibodies by Immune Repertoire Mining. Scientific reports, 5, 13926. DOI:10.1038/srep13926
DeKosky, B. J., Kojima, T. Rodin, A. Charab, W. Ippolito, G. C., Ellington, A. D., & Georgiou, G. (2015). In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoire. Nature medicine, 21(1), 86-91. DOI:10.1038/nm.3743
Doria-Rose, N. A., Schramm, C. A., Gorman, J. Moore, P. L., Bhiman, J. N., DeKosky, B. J., Ernandes, M. J., Georgiev, I. S., Kim, H. J., Pancera, M. Staupe, R. P., Altae-Tran, H. R., Bailer, R. T., Crooks, E. T., Cupo, A. Druz, A. Garrett, N. J., Hoi, K. H., Kong, R. Louder, M. K., Longo, N. S., McKee, K. Nonyane, M. O'Dell, S. Roark, R. S., Rudicell, R. S., Schmidt, S. D., Sheward, D. J., Soto, C. Wibmer, C. K., Yang, Y. Zhang, Z. Mullikin, J. C., Binley, J. M., Sanders, R. W., Wilson, I. A., Moore, J. P., Ward, A. B., Georgiou, G. Williamson, C. Abdool Karim, S. S., Morris, L. Kwong, P. D., Shapiro, L. & Mascola, J. R. (2014). Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies. Nature, 509(7498), 55-62. DOI:10.1038/nature13036
Lavinder, J. J., Wine, Y. Giesecke, C. Ippolito, G. C., Horton, A. P., Lungu, O. I., Hoi, K. H., DeKosky, B. J., Murrin, E. M., Wirth, M. M., Ellington, A. D., Dörner, T. Marcotte, E. M., Boutz, D. R., & Georgiou, G. (2014). Identification and characterization of the constituent human serum antibodies elicited by vaccination. Proceedings of the National Academy of Sciences of the United States of America, 111(6), 2259-64. DOI:10.1073/pnas.1317793111
DeKosky, B. J., Ippolito, G. C., Deschner, R. P., Lavinder, J. J., Wine, Y. Rawlings, B. M., Varadarajan, N. Giesecke, C. Dörner, T. Andrews, S. F., Wilson, P. C., Hunicke-Smith, S. P., Willson, C. G., Ellington, A. D., & Georgiou, G. (2013). High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nature biotechnology, 31(2), 166-9. DOI:10.1038/nbt.2492
DeKosky, B. J., Dormer, N. H., Ingavle, G. C., Roatch, C. H., Lomakin, J. Detamore, M. S., & Gehrke, S. H. (2010). Hierarchically designed agarose and poly(ethylene glycol) interpenetrating network hydrogels for cartilage tissue engineering. Tissue engineering. Part C, Methods, 16(6), 1533-42. DOI:10.1089/ten.tec.2009.0761
Selected Awards & Honors
Cellular and Molecular Bioengineering Rising Star
Biomedical Engineering Society
2017